Ex Parte Zasloff et al - Page 14


              Appeal No. 2007-0055                                                               Page 14                 
              Application No. 10/053,299                                                                                 

              Examiner.  Answer 21.  Appellants have not provided persuasive arguments to the                            
              contrary.                                                                                                  
                     The rejection of claim 1 under § 103(a) is affirmed, but subject to a new ground                    
              of rejection under 37 CFR § 41.50(b) based on a claim interpretation that is different                     
              from the Examiner’s.                                                                                       
                     Claims 5-10, 41, 42, and 43 fall with claim 1 since they were not separately                        
              argued.                                                                                                    
                     Claims 2, 3, and 4                                                                                  
                     Claims 2-4 recite ranges of isoleucine per cm2 of eukaryotic cell surface.  The                     
              Examiner states that the claim ranges overlap with the ranges described by Zeng.                           
              However, the Examiner argues that “it would have been deemed obvious to one of                             
              ordinary skill in the art at the time the invention was made to determine suitable ranges                  
              or amounts . . . through the use of routine or manipulative experimentation to obtain the                  
              best possible results, as these are variable parameters within the art.”  Answer, pages                    
              15-16.                                                                                                     
                     We agree with Appellants that the Examiner has not established a prima facie                        
              case of unpatentability for these claims.  Although an overlap in ranges establishes                       
              prima facie obviousness, an exception has been recognized where a parameter had not                        
              been recognized as being a “result-effective variable.”  In re Antonie, 559 F.2d 618, 620,                 
              195 USPQ 6, 8-9 (CCPA 1977).  Concentration is identified by Zeng as a results-                            
              effective variable for reducing vaginal acidity, but the Examiner has not provided                         
              sufficient evidence that, in optimizing the ranges for this activity, the microbial blocking               
              activity would also be realized.  This problem is further compounded because we can                        




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