Ex parte SINGH et al. - Page 2




          Appeal No. 95-0865                                                           
          Application 08/08/007,950                                                    

          Part II "Summary of Action"), which are all of the claims in the             
          application on appeal.  We reverse, but enter new grounds of                 
          rejection pursuant to 37 CFR § 1.196(b) as to Claims 6-9, 11-17,             
          19-22 and 25.  We do not enter new grounds of rejection as to                
          Claims 10 and 18.                                                            

               A.   Findings of fact                                                   
               The record supports the following findings by a                         
          preponderance of the evidence.                                               

                                    The invention                                      
                    1.   The invention relates to a process for making                 
          2-amino-6-halo-9-[2,3-disubstituted-cyclobutyl]-purines.                     
                    2.   The invention also relates to converting the                  
          purines to known antiviral agents, e.g., [1R-(1",2$,3")]-2-amino-            
          9-[2,3-bis(hydroxymethyl)-cyclobutyl]-1,9-dihydro-6H-purin-6-one.            
                    3.   A 9-cyclobutane purine ring has the following                 
          structure and                                                                
          numbering system:                                                            








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